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The clinical benefits of semaglutide (Wegovy) went beyond expectations in the SELECT trial, given the reductions in non-cardiovascular and infectious disease deaths observed.

Among people with overweight or obesity and pre-existing cardiovascular disease, the drop in all-cause deaths associated with weekly semaglutide injections versus placebo was broken down to a nonsignificant trend toward less cardiovascular death while non-cardiovascular deaths were significantly reduced.

The present results support "the hypothesis that there may be several mechanisms that led to the reduction in CV [cardiovascular] and non-CV death, some of which may be unrelated to atherothrombosis," Scirica and colleagues wrote of their prespecified SELECT analysis, simultaneously published in the Journal of the American College of Cardiology. Head over to MedPage Today to read more about it.